The Producer and Biological Activities of So-075r1, a New Mutactimycin Group Antibiotic
نویسندگان
چکیده
The producer of SO-075R1,a newanthracycline group antibiotic was identified as Nocardia brasiliensis. SO-075R1 was active against Gram-positive bacteria, but not active against Gram-negative bacteria or fungi. All tested Nocardia brasiliensis strains as well as the producer itself were resistant to SO-075R1, although four other pathogenic Nocardia, i.e. N. asteroides, N. nova, N. farcinica and N. otitidiscaviarum were sensitive.
منابع مشابه
Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains.
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against...
متن کاملSO-75R1, a new mutactimycin derivative produced by Nocardia brasiliensis.
In the course of studies on biologically active substances from pathogenic microorganisms, a new antibiotic SO-75R1 was isolated from the mycelium of Nocardia brasiliensis IFM 075. This paper describes the fermentation, isolation and structural elucidation of SO-75R1. The seed broth was prepared by inoculating mycelial elements of the producing strain (IFM 075) grown on Sabouraud dextrose agar ...
متن کاملProspects for Success in Inhibiting the Growth of Multidrug-resistant Bacteria with Paromomycin
Streptomyces is the most important bacterial genus known to produce secondary antibiotic compounds. Considering the speed of bacterial resistance spread, it becomes more important to study less used compounds. Aminoglycosides disrupt the function of the target microorganism by acting on the protein-synthesis process. Paromomycin is an aminoglycoside that acts on a wide range of gram-positive, g...
متن کاملInterspecies interactions of halophilic and halotolerant actinomycetes: An example from a salt
Interspecies interaction of actinomycetes will express new gene clusters and may therefore affect the pigmentation, sporulation and production of secondary metabolites. Actinomycetes strains were isolated from Howze Soltan Salt Lake. Binary actinomycete interaction assay was conducted to evaluate its effect on colony morphology and antibiotic production. The molecular identification of the indu...
متن کاملNew update on molecular determinants of colistin resistance in bacteria
Colistin relates to the polymyxin group of antibiotics. This antibiotic is still used to destroy gram-negative bacteria as a last resort. However, resistance to this antibiotic has been reported and is appearing day by day. Not much information is available on the exact mechanisms of resistance to this antibiotic. Also, not enough information about pharmacokinetics and pharmacodynamics is avail...
متن کامل